PRK AND ROCK ARE REQUIRED FOR THROMBIN-INDUCED ENDOTHELIAL CELL PERMEABILITY DOWNSTREAM FROM Gα12/13 and Gα11/q
نویسندگان
چکیده
PRK AND ROCK ARE REQUIRED FOR THROMBIN-INDUCED ENDOTHELIAL CELL PERMEABILITY DOWNSTREAM FROM Gα12/13 and Gα11/q Julie Gavard and J Silvio Gutkind From 1 Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 Running head: RhoA bifurcation on ROCK and PRK *Address correspondance to: Julie Gavard, Ph.D., CNRS, UMR8104, INSERM, U567, Université Paris Descartes, Institut Cochin, 22 rue Méchain, 75014 Paris, France. Fax: +33140516430. Email: [email protected]
منابع مشابه
Molecular characterization of the effects of Y-27632.
Many key cellular functions, such as cell motility and cellular differentiation are mediated by Rho-associated protein kinases (ROCKs). Numerous studies have been conducted to examine the ROCK signal transduction pathways involved in these motile and contractile events with the aid of pharmacological inhibitors such as Y-27632. However the molecular mechanism of action of Y-27632 has not been f...
متن کاملRho signalling at a glance.
Cells receive extracellular stimuli in the form of soluble molecules (growth factors, cytokines and hormones) that bind to cell surface receptors, adhesive interactions (extracellular matrix and cell-cell adhesion) or mechanical stresses (tension, compression and fluid shear stress). These stimuli act upon guanine-nucleotide-exchange factors (GEFs) and GTPase-activating proteins (GAPs) to contr...
متن کاملDynamic, Rho1p-dependent localization of Pkc1p to sites of polarized growth.
In eukaryotes, the Rho GTPases and their effectors are key regulators of the actin cytoskeleton, membrane trafficking and secretion, cell growth, cell cycle progression and cytokinesis. Budding yeast Pkc1p, a protein kinase C-like enzyme involved in cell wall biosynthesis and cytoskeletal polarity, is structurally and functionally related to the Rho-associated kinases (PRK/ROCK) of mammalian ce...
متن کاملThe PIF-pocket regulatory site in AGC kinases: relevance for cellular physiology and innovative therapies
The group of AGC protein kinases includes more than 60 protein kinases in the human genome (e.g. PDK1 and isoforms of PKA, PKC, PRK, PKB/Akt, S6K, SGK, RSK, MSK, ROCK, GRK, amongst others). This group is also widely represented in other eukaryotes, including organisms that cause human infectious diseases. Human AGC kinases are involved in diverse cellular functions and are potential targets for...
متن کاملGains from diversification on convex combinations: A majorization and stochastic dominance approach
By incorporating both majorization theory and stochastic dominance theory, this paper presents a general theory and a unifying framework for determining the diversification preferences of risk-averse investors and conditions under which they would unanimously judge a particular asset to be superior. In particular, we develop a theory for comparing the preferences of different convex combination...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008